I don’t know what the best weight loss pills out there are but I do have one question for you. Do you want to have wrinkle-free skin? Avoid the sun. It’s the No. 1 cause of wrinkles, with dozens of studies documenting the impact.  Retinoids (including Retin A). The only FDA-approved topical treatment for wrinkles is tretinoin, known commercially as Retin A. Ashinoff says this prescription cream reduces fine lines and large wrinkles, and repairs sun damage. Retinol is a natural form of vitamin A found in many over-the-counter products. Studies show that in a stabilized formula, in high concentrations, it may be as effective as Retin A, without the side effects, such as skin burning and sensitivity.  Pentapeptides can increase collagen production in sun-damaged skin. Several subsequent studies (including one presented at a recent national dermatology conference) showed that when topically applied, pentapeptides stimulated collagen production and diminished lines and wrinkles. You could always try Wrinkle fillers. Doctors fill wrinkles with a variety of substances, including collagen, hyaluronic acid, and other synthetic compounds. Popular treatments include Restylane, Juvederm, and ArteFill, among others.  Laser/light resurfacing. Here, energy from a light source — either a laser or a pulsed diode light — removes the top layer of skin, causing a slight but unnoticeable skin “wounding.” This kicks the skin’s natural collagen-production system into high gear, resulting in smoother, more wrinkle-free skin.